Antioxidants are compounds that can counteract or reduce the negative effects of oxidants in the body. Antioxidants produced by the human body are not enough to fight free radicals, therefore the body needs antioxidant intake from outside such as from supplements or cosmetics. The purpose of this literature review research is to find out the application of patchouli oil as a natural antioxidant in cosmetic preparations through a literature search that can be a reference in further research. The systematic review method was carried out by collecting data from various literature sources obtained from several research journals that have been accredited both nationally and internationally that study cosmetics that use patchouli oil as a natural antioxidant.Based on the systematic review, antioxidants contained in patchouli oil are needed in cosmetic preparations because they are able to restore skin lesions damaged by UV exposure and can reduce free radicals. Some cosmetic preparations that use patchouli oil as an antioxidant are soap, sleeping mask, facial wash, lotion, shampoo and deodorant.