USK Conferences, The 1st Syiah Kuala International Conference on Medical and Health Sciences

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Biochemical And Haematology Result Interpretation In Children
Desiana .

Date: 2017-05-11 04:00 PM – 04:30 PM
Last modified: 2017-06-06

Abstract


Most laboratories can now competently analyse small samples without much effect on workflow and consequent productivity, but this does not guarantee that the information provided is adequate for the needs of the referring clinician. The results must be interpreted with a knowledge of the factors that affect children's biochemistry. In hematology testing Children add an additional layer of complexity to each of these issues. For example, issues related to sample collection and the use of capillary blood are particularly relevant causes of spurious results. Perhaps the most misunderstood issue is the concept of 'normal' in different age groups. Countless children are misdiagnosed or over-investigated because of a lack of understanding that they are not just 'little adults', but are physiologically different in many respects. This lack of understanding often extends to the laboratory reporting the results. The clinician may be led astray by reports that would be correct for adult patients, but are non-contributory or wrong in children. The consequential small blood sample volume is also more susceptible to the deleterious effects of light, heat, contamination and evaporation than larger-volume venous collections. A frequently encountered problem in small samples is the loss of carbon dioxide into the remaining air space in the tube, leading to falsely low bicarbonate values. The use of inappropriately large specimen containers will exacerbate this and other problems. These factors occasionally generate aberrant results which can only be clarified by repeat collection and analysis. Interpretation of laboratory results from paediatric patients may be made difficult by a number of factors. Where uncertainty remains, it may be advisable to refer further testing to a laboratory which receives relatively larger numbers of paediatric samples and which should consequently have more data and greater experience at interpreting the results.


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